EC3, a Novel Heterodimeric Disintegrin from Echis carinatus Venom, Inhibits α4 and α5 Integrins in an RGD-independent Manner
نویسندگان
چکیده
منابع مشابه
Enzymatic Analysis of Iranian Echis carinatus Venom Using Zymography
Snakebite is a common problem especially in tropical areas all over the world including Iran. Echis carinatus as one of the most dangerous Iranian snakes is spreading in this country excluding central and northwest provinces. In this study gelatinase and fibrinogenolytic properties as two disintegrating matrix metalloproteinase enzymes were evaluated by a strong clear halo between 56-72 kDa in ...
متن کاملPartial Purification and Characterization of Anticoagulant Factor from the Snake (Echis Carinatus) Venom
OBJECTIVE(S) Snake venoms contain complex mixture of proteins with biological activities. Some of these proteins affect blood coagulation and platelet function in different ways. Snake venom toxin may serve as a starting material for drug design to combat several pathophysiological problems such as cardiovascular disorders. In the present study, purification of anticoagulation factor from venom...
متن کاملProteins from Mucuna pruriens and enzymes from Echis carinatus venom: characterization and cross-reactions.
Mucuna pruriens seeds have been widely used against snakebite in traditional medicine. The antivenin property of a water extract of seeds was assessed in vivo in mice. The serum of mice treated with extract was tested for its immunological properties. Two proteins of Echis carinatus venom with apparent molecular masses of 25 and 16 kDa were detected by Western blot analysis carried out using Ig...
متن کاملPreparation, characterization and stability investigation of chitosan nanoparticles loaded with the Echis carinatus snake venom as a novel delivery system
The chitosan nanoparticles used widely as a drug delivery systems recently. In the present study the Echis carinataus snake venom loaded chitosan nanoparticles were prepared based on ionic gelation of tripolyphosphate and chitosan. The nanoparticles physicochemical characteristics, stability and biological activity of encapsulated venom were studied. The particles were spherical in shape and th...
متن کاملA New Approach to Antivenom Preparation Using Chitosan Nanoparticles Containing Echis Carinatus Venom as A Novel Antigen Delivery System
In recent years, use of biodegradable polymers based nanoparticles has received highinterest in the development of vaccines delivery vehicles. The aim of study was to preparechitosan nanoparticles (CS NPs) for loading Echis carinatus (EC) venom and evaluate theirpotential as an adjuvant and antigen delivery system on a pilot scale. CS NPs were preparedusing ionic gelation method, and their char...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1999
ISSN: 0021-9258
DOI: 10.1074/jbc.274.18.12468